1906 – NAD was discovered by Arthur Harden and William John Young.
1929 – Hans von Euler-Chelpin won the Nobel Prize with Arthur Harden for their investigation into fermentation
1936 – Otto Heinrich Warburg showed how NAD functions in fermentation reactions.
1938 – Conrad Elvehjem discovered “anti-black tongue factor,” the first vitamin precursors of NAD.
1940 – Arthur Kornberg discovered the first NAD biosynthetic enzyme.
1958 – Jack Preiss and Philip Handler discovered the pathway through which nicotinic acid is converted into NAD.
1963 – Mandel and colleagues described the first chemical reaction in which NAD is broken down to its component parts.
2000 – Leonard Guarente and co-workers discovered that Sirtuin enzymes break NAD into its component parts.
2004 – Charles Brenner and co-workers discovered a new NAD precursor and the pathway through which nicotinamide riboside is converted into NAD.