1906 – NAD was discovered by Arthur Harden and William John Young.
![](https://sirtuinshealth.com/wp-content/uploads/2019/01/Screenshot_2019-01-07-History-on-NAD-a-Timeline-of-Events-AboutNAD.png)
1929 – Hans von Euler-Chelpin won the Nobel Prize with Arthur Harden for their investigation into fermentation
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1936 – Otto Heinrich Warburg showed how NAD functions in fermentation reactions.
![](https://sirtuinshealth.com/wp-content/uploads/2019/01/Screenshot_2019-01-07-History-on-NAD-a-Timeline-of-Events-AboutNAD2.png)
1938 – Conrad Elvehjem discovered “anti-black tongue factor,” the first vitamin precursors of NAD.
![](https://sirtuinshealth.com/wp-content/uploads/2019/01/Screenshot_2019-01-07-History-on-NAD-a-Timeline-of-Events-AboutNAD3.png)
1940 – Arthur Kornberg discovered the first NAD biosynthetic enzyme.
![](https://sirtuinshealth.com/wp-content/uploads/2019/01/Screenshot_2019-01-07-History-on-NAD-a-Timeline-of-Events-AboutNAD4.png)
1958 – Jack Preiss and Philip Handler discovered the pathway through which nicotinic acid is converted into NAD.
![](https://sirtuinshealth.com/wp-content/uploads/2019/01/Screenshot_2019-01-07-History-on-NAD-a-Timeline-of-Events-AboutNAD5.png)
1963 – Mandel and colleagues described the first chemical reaction in which NAD is broken down to its component parts.
![](https://sirtuinshealth.com/wp-content/uploads/2019/01/Screenshot_2019-01-07-History-on-NAD-a-Timeline-of-Events-AboutNAD6.png)
2000 – Leonard Guarente and co-workers discovered that Sirtuin enzymes break NAD into its component parts.
![](https://sirtuinshealth.com/wp-content/uploads/2019/01/Screenshot_2019-01-07-History-on-NAD-a-Timeline-of-Events-AboutNAD7.png)
2004 – Charles Brenner and co-workers discovered a new NAD precursor and the pathway through which nicotinamide riboside is converted into NAD.
![](https://sirtuinshealth.com/wp-content/uploads/2019/01/Screenshot_2019-01-07-History-on-NAD-a-Timeline-of-Events-AboutNAD8.png)