1906 – NAD was discovered by Arthur Harden and William John Young. 1929 – Hans von Euler-Chelpin won the Nobel Prize with Arthur Harden for their investigation into fermentation 1936 – Otto Heinrich Warburg showed how NAD functions in fermentation reactions.  1938 – Conrad Elvehjem discovered “anti-black tongue factor,” the first vitamin precursors of NAD. 1940 – Arthur Kornberg discovered the…

Sirtuins and NAD+ in Aging / Longevity Control Source: Nature MagazineAbstractThe coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a mechanistic foundation that translates the regulation of energy metabolism into aging and longevity control in…

Article from PUBMED:NAD+ and sirtuins in aging and disease. AbstractNicotinamide adenine dinucleotide (NAD(+)) is a classical coenzyme mediating many redox reactions. NAD(+) also plays an important role in the regulation of NAD(+)-consuming enzymes, including sirtuins, poly-ADP-ribose polymerases (PARPs), and CD38/157 ectoenzymes. NAD(+) biosynthesis, particularly mediated by nicotinamide phosphoribosyltransferase (NAMPT), and SIRT1 function together to regulate metabolism and circadian rhythm. NAD(+) levels decline…

What Are Sirtuins? In short, Sirtuins are Protein Enzymes that help turn on and off genes offering protection in Cells of Our Physical Bodies to Combat Stress and Metabolic Regulation. History in the Making Harvard's David Sinclair in mid 2000s brought Our Awareness to Reveratrol, the red wine ingredient. Since then, in 2013, NMN understanding has been brought into the picture.…