1906 – NAD was discovered by Arthur Harden and William John Young. 1929 – Hans von Euler-Chelpin won the Nobel Prize with Arthur Harden for their investigation into fermentation 1936 – Otto Heinrich Warburg showed how NAD functions in fermentation reactions.  1938 – Conrad Elvehjem discovered “anti-black tongue factor,” the first vitamin precursors of NAD. 1940 – Arthur Kornberg discovered the…

Sirtuins and NAD+ in Aging / Longevity Control Source: Nature MagazineAbstractThe coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a mechanistic foundation that translates the regulation of energy metabolism into aging and longevity control in…

Article from PUBMED:NAD+ and sirtuins in aging and disease. AbstractNicotinamide adenine dinucleotide (NAD(+)) is a classical coenzyme mediating many redox reactions. NAD(+) also plays an important role in the regulation of NAD(+)-consuming enzymes, including sirtuins, poly-ADP-ribose polymerases (PARPs), and CD38/157 ectoenzymes. NAD(+) biosynthesis, particularly mediated by nicotinamide phosphoribosyltransferase (NAMPT), and SIRT1 function together to regulate metabolism and circadian rhythm. NAD(+) levels decline…